About this material

• This material has been created for the purpose of providing scientific information and is not intended to promote our products.
• This material is reprinted with permission from the rights holders.
• The final diagnosis and treatment decisions of individual cases are the responsibility of the treating healthcare professional.
• This material is intended for healthcare professionals only. Unauthorized reproduction or distribution is prohibited.

Welcome to our website!

Thank you for coming to learn and discover more about the diagnosis of glomerular diseases. Chronic kidney disease has a global prevalence of 9.1% and is now one of the twelve leading causes of death worldwide.¹ The main causes of CKD are hypertension and diabetes. In third place among the causes, glomerular diseases contribute to almost a fifth of all cases of chronic kidney disease.²

With this collection of glomerular patient cases, we want to show you how an initially unspecific patient presentation can lead to a diagnosis. Insights into the patho-zooms will show you how pathogenic changes in the glomeruli present themselves and which descriptions can be found in the pathologist’s report.

We hope that you will find clues for your everyday clinical work in the patient cases. Some of the glomerular diseases are rare, so it is important to have support for the diagnosis at hand when confronted with them. We hope that you can find this on our Educational Platform.

Yours sincerely, Novartis Medical Team.

1) GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 395(10225):709–733 (2020); 2) Titze et al., Nephrol Dial Transplant, 2015;30:441–451.

Navigation: The patient cases are organised in 3 levels so that you can find the following information for each case:

• General information on the patient case (medical history, laboratory findings, indication for biopsy, etc.)
• Patho-zoom images of the nephropathological processing of the biopsies (various stains, immunohistochemical images, etc.)
• Description of findings from the nephropathologist’s report.

You can initially view this information for each case and develop your own diagnosis for each case based on the case presentation and description as well as your own review of the biopsy slides (level 1).
At the bottom of each case, you can then select the following aspects by clicking on the buttons to obtain more information:

• Show annotations: Annotations from the nephropathologist show you which areas in the biopsy scan should be classified as pathological. Perhaps this will change your previous diagnosis? (level 2)
• Show final diagnosis: This allows you to check at the end which diagnosis actually formed the basis of the case presented. (Stage 3)

Have fun developing your glomerular diagnosis skills.